Amphetamine, Energy Drinks and Associated Problems

Amphetamine is a psycho-stimulant drug which was first synthesized in 1887 by Lazăr Edeleanu, a Romanian chemist.

No pharmacological use was found for amphetamine until 1929, when psycho-pharmacologist Gordon Alles, in search of an allergy drug remedy, re-synthesized and tested it on himself. He noted a “feeling of well being,” “palpitation,” and eventually a “sleepless night” in which his “mind seemed to race from one subject to another.”(1)

A few years later a new drug dubbed “Benzedrine”, based on Alles re-synthesized amphetamine compound, was released on the market by the Philadelphia firm Smith, Kline and French as a decongestant inhaler.

The company then began to look for more commercial outlets for amphetamine in a wide range of medical specialties. The use that stirred interest among neuro-psychiatrists was for therapy of common, milder depressions. Amphetamine represented the first of the anti-depressant drugs and its use soon spread to general practice. (2)

However, the use of amphetamine soon spread outside general practice. By early 1937, abuse of the drug was reported among mid-western college students, and amphetamine tablets were taking on a new identity as “pep pills” or “pepper-uppers.” Students were mostly taking amphetamine while studying for, or actually taking, exams.(3)

After decades of reported abuse, the Food and Drug Administration (FDA) limited amphetamine to prescription use in 1965, but non-medical use remained common. In 1971, amphetamine became a schedule II drug, under the Controlled Substances Act.

A schedule II drug is classified as one that has a high potential for abuse, severe physiological and psychological dependence, and has a currently-accepted medical use, such as d-amphetamine used to treat attention deficit hyperactivity disorder (ADHD). (4)

More recently, many students have turned to a legal stimulant to aid their performance – the ‘energy drink’. Energy drinks are soft drinks advertised as boosting energy. These drinks usually contain a variety of stimulants, vitamins, and herbal supplements the manufacturer has combined.(5)

The central ingredient in most energy drinks is caffeine, the same stimulant found in coffee or tea, often in the form of guarana or yerba mate. Caffeine is found in varying quantities in the beans, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants.

“The caffeine content of energy drinks varies over a 10-fold range, with some containing the equivalent of 14 cans of Coca-Cola, yet the caffeine amounts are often unlabeled and few include warnings about the potential health risks of caffeine intoxication,” says Roland Griffiths, Ph.D., an author of an article that appears in the journal Drug and Alcohol Dependence.(6)

Caffeine Jitters

An acute overdose of caffeine usually in excess of about 300 milligrams, dependent on body weight and level of caffeine tolerance, can result in a state of central nervous system over-stimulation called caffeine intoxication or informally the “caffeine jitters”.

Caffeine intoxication is a recognized clinical syndrome included in the Diagnostic and Statistical Manual of Mental Disorders and the World Health Organisation’s International Classification of Diseases.

It is marked by;

  • nervousness
  • anxiety
  • restlessness
  • insomnia
  • gastrointestinal upset
  • tremors
  • rapid heartbeats (tachycardia) and;
  • psychomotor agitation (restlessness and pacing).

A major concern is that without adequate, prominent labeling, consumers most likely won’t realize whether they are getting a little or a lot of caffeine.

“It’s like drinking a serving of an alcoholic beverage and not knowing if its beer or scotch,” says Griffiths.

However, with energy drinks no warning labels are warranted. Because many energy drinks are marketed as “dietary supplements,” the limit that the FDA requires on the caffeine content of soft drinks (71 milligrams per 12-ounce can) does not apply. The caffeine content of energy drinks varies from 50 to more than 500 milligrams.

Griffiths also notes that most of the drinks advertise their products as performance enhancers and stimulants – a marketing strategy that may put young people at risk for abusing even stronger stimulants.

This view is substantiated by a 2008 study of 1,253 college students which found that energy drink and associated caffeine consumption significantly predicted subsequent non-medical prescription stimulant use, raising the concern that energy drinks might serve as “gateway” products to more serious abuse of drugs. (7)

Stimulants such as amphetamine and energy drinks alter behavioral effects in the brain by modulating several key neurotransmitters, including dopamine, serotonin, and melatonin which function to regulate appetite, sleep, memory, learning, temperature, and mood.

More specifically, if the melatonin signal – which forms part of the system that regulates the sleep-wake cycle by chemically causing drowsiness and lowering the body temperature – is inhibited, functional ability will be limited. Similarly, research into mood has speculated inhibition of serotonin levels have a role in depression.

Research shows that depression and other mental disorders, or a substance-abuse disorder (often in combination with other mental disorders) are risk factors for suicide. More than 90 percent of people who die by suicide have these risk factors. (Facts about suicide)

It also shows:

  • A person dies by suicide about every 18 minutes in the U.S.  An attempt is estimated to be made once every minute.
  • Suicide is the second leading cause of death among college students and the third leading cause of death among all youth 15–24 years old.
  • Seventy percent of youth who make a suicide attempt are frequent users of alcohol and/or other drugs.
  • The rates of depression in younger people have steadily grown to outnumber rates of depression in the older populations.(8)

So what’s behind the rising rates of depression among young people?

A statistical modeling study suggests that problems with alcohol abuse may lead to an increased risk of depression, as opposed to the reverse model in which individuals with depression self-medicate with alcohol, according to a report in the March (2009) issue of Archives of General Psychiatry.(9)

However, some researchers think loss of healthy bacteria may have an effect. Emory neuro-scientist Charles Raison, MD, and colleagues say there is mounting evidence that disruptions in ancient relationships with microorganisms in soil, food and the gut may contribute to the increasing rates of depression. (10) (see… A benefit of flu: protection from asthma?)

According to the authors, the modern world has become so clean, we are deprived of the bacteria our immune systems came to rely upon over long ages to keep inflammation at bay.

“We have known for a long time that people with depression, even those who are not sick, have higher levels of inflammation,” explains Raison.

Inflammation is the body’s immune response to irritation, injury, or trauma. The immune system is complex – different types of immune cells and proteins do different jobs.

cytokines and inflammatory response

Cytokines are among those proteins which are released by cells into the circulation or directly into tissue.  The release triggers, or stimulates, specific responses by the target cells.(11)

Overproduction or inappropriate production of certain cytokines by the body can result in disease. Furthermore severe depressive illness is accompanied by signs of immune activation and by elevations of cytokine production or levels.(12)

Raison says:  “Since ancient times benign microorganisms, some times referred to as ‘old friends,’ have taught the immune system how to tolerate other harmless microorganisms, and in the process, reduce inflammatory responses that have been linked to the development of most modern illnesses, from cancer to depression.”

In the December 15 , 2010 issue of Cancer Research, scientists say they can now definitively show that an inflammatory process within the breast itself promotes growth of breast cancer stem cells responsible for tumor development.(13)

Researchers, led by Richard G. Pestell, M.D., Ph.D, found that if they selectively blocked inflammation just in the breast, tumors would not develop.

So, is a clean environment, as Raison suggests, the main culprit for the onset of inflammation and modern disease? Or do other factors play a part, such as the stimulants amphetamine and caffeine?

Let’s turn our attention to caffeine, the main ingredient in most energy drinks.

 

Caffeine enters the bloodstream through the stomach and small intestine and can have its effects as soon as 15 minutes after it is consumed. Once in the body, caffeine will stay around for hours: it takes about 6 hours for one half of the caffeine to be eliminated. (14)

One of the negative effects of caffeine is its ability to disrupt sleep cycles, causing less deep sleep, particularly when you have caffeinated beverages within a few hours of bedtime.

Night-shift workers especially should avoid drinking coffee if they wish to improve their sleep, according to new research. A study led by Julie Carrier, a University of Montreal psychology professor has found the main byproduct of coffee, caffeine, interferes with sleep and this side-effect worsens as people age. (15)

Circadian Rhythm

Scientists suspect that overnight work, and subsequent altered sleep patterns, is dangerous because it disrupts the circadian rhythm, the body’s biological clock. This disruption can result in inhibition of the hormone melatonin, which can suppress tumor development, and is normally produced at night. Disruption of circadian rhythms has been classified as a probable cause of human cancer by the International Agency for Research on Cancer.

Among the first to spot the night shift-cancer connection was Richard Stevens, a cancer epidemiologist and professor at the University of Connecticut Health Center. In 1987, Stevens published a paper suggesting a link between light at night and breast cancer. He was trying to figure out why breast cancer incidence suddenly shot up starting in the 1930s in industrialized societies, where night-time work was considered a hallmark of progress. (16)

Animals that have their light-dark schedules switched develop more cancerous tumors and die earlier. In humans, sleep deprivation and the ensuing melatonin suppression lead to immunodeficiency. For example, sleep deprivation suppresses natural killer-cell activity and alters cytokine balance, reducing cellular immune defense.(17)

Recent research with animal models (animals with a disease that is similar to or the same as a disease in humans) suggests that the body’s neuro-endocrine response (release of hormones into the blood in response to stimulation of the nervous system) can directly alter important processes in cells that help protect against the formation of cancer, such as DNA repair and the regulation of cell growth.(18)

Akio Ohta et al reason if caffeine activates bio-chemical targets, it is important to test whether the consumption of caffeine during an acute inflammation episode would lead to the exacerbation of immune-mediated tissue damage. They examined treatment with caffeine for its effects on acute liver inflammation. It was shown that caffeine at lower doses (10 and 20 mg/kg) strongly exacerbated acute liver damage and increased levels of pro-inflammatory cytokines.(19)

One of the main reasons for liver damage is chronic alcohol consumption. As the liver heals from alcohol metabolism, it begins to scar (cirrhosis of the liver) from continual regeneration. The damage interferes with regulatory processes like metabolism of proteins, and carbohydrates, causing malnutrition and toxicity in the blood.(20)

People who have poor general health resulting from liver disease and large amounts of alcohol consumption run the risk of developing serious and persistent changes in the brain.(21)

In a study with human postmortem brains Crews et al found, neuro-inflammation and levels of pro-inflammatory cytokine were significantly higher in the brains of alcoholics than the brains of control, moderate-drinking individuals.  Crews’ findings suggest that excessive alcohol consumption sets off a spreading cytokine process.(22)

University of Illinois animal sciences professor Rodney Johnson believes excessive cytokine production in the brain causes associated problems. He states:

“We think this contributes to cognitive aging and is a predisposing factor for the development of neuro-degenerative diseases.” (23)

A number of proposed mechanisms for depression appear to be similar to those implicated in neuro-degenerative diseases.  For example, neuro-inflammation observed in depression are found to be associated with the development of Alzheimers disease .(24)

It would appear the over production of cytokines causing major inflammatory problems, initiated by excessive alcohol consumption and exacerbated by both caffeine intake and sleep deprivation, are associated with major health problems such as depression and cancer.

A drug commonly used to treat depression is the prescribed anti-depressant duloxetine, or cymbalta which has recently been reported to be effective at reducing joint and muscle pain associated with breast cancer treatment. It is believed to decrease pain through its actions in the central nervous system.(25)

However, the FDA requires all anti-depressants, including duloxetine, to carry a black box warning stating that anti-depressants may increase the risk of suicide in persons younger than 25. This warning is based on statistical analyzes conducted by FDA experts that found a 2-fold increase of suicidal behavior in children and adolescents, and 1.5-fold increase of suicide in the 18–24 age group.(26)

In addition, interview data from the U.S.A.’s Third National Cancer Survey, suggested along with alcohol ingestion, several common drugs acting in a similar manner could be cancer promoters. The drugs, including d-amphetamine and tricyclic anti-depressants, were associated with a higher occurrence of cancers of the breast, thyroid, and malignant melanoma. Over 20,000 (25%) of all new breast-cancer cases each year in the U.S.A. could be preventable if this hypothesis is correct.(27)

Anti-depressants don’t appear to be a healthy option for young people.

luteolin

luteolin rich foods

What about luteolin, a compound found in many plants, including carrots, peppers, celery, olive oil, peppermint, rosemary and chamomile.

Should this be added to energy drinks?

Why?

Rodney Johnson, who has spent nearly a decade studying the anti-inflammatory properties of nutrients and various bio-active plant compounds, suggests that luteolin improves cognitive health by acting directly on microglial cells to reduce their production of inflammatory cytokines in the brain.(28)

The researchers showed microglial cells that were exposed to a bacterial toxin produced inflammatory cytokines that could kill neurons. When the microglia were exposed to luteolin before they encountered the toxin, however, the neurons lived.

“The neurons survived because the luteolin inhibited the production of neuro-toxic inflammatory mediators,” Johnson said.

Exposing only the neurons to luteolin before the experiment had no effect on their survival, the researchers found.

“This demonstrated that luteolin isn’t protecting the neurons directly,” he said. “It’s doing it by affecting the microglial cells.

“These data suggest that consuming a healthy diet has the potential to reduce age-associated inflammation in the brain, which can result in better cognitive health,” he adds.

Better cognitive health resulting in reduced depression and suicide rates.  Now that helps me sleep better at night.

………………………………………………………………………….

Need Help?

suicide help and prevention

worldwide suicide help

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Latest news

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    ****

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    what you guys {are|are usually|tend to be} up too.
    {This sort of|This type of|Such|This kind of} clever work and {exposure|coverage|reporting}!
    Keep up the {superb|terrific|very good|great|good|awesome|fantastic|excellent|amazing|wonderful} works guys I’ve {incorporated||added|included} you guys
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    {Howdy|Hi there|Hey there|Hi|Hello|Hey}! Someone in my {Myspace|Facebook} group shared this {site|website} with us so I came
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    I’m definitely {enjoying|loving} the information.
    I’m {book-marking|bookmarking} and will be tweeting this to my followers!
    {Terrific|Wonderful|Great|Fantastic|Outstanding|Exceptional|Superb|Excellent} blog and {wonderful|terrific|brilliant|amazing|great|excellent|fantastic|outstanding|superb} {style and
    design|design and style|design}.|
    {I love|I really like|I enjoy|I like|Everyone loves} what you
    guys {are|are usually|tend to be} up too.
    {This sort of|This type of|Such|This kind of} clever work and {exposure|coverage|reporting}!
    Keep up the {superb|terrific|very good|great|good|awesome|fantastic|excellent|amazing|wonderful} works guys I’ve {incorporated|added|included} you guys to {|my|our|my personal|my own} blogroll.|
    {Howdy|Hi there|Hey there|Hi|Hello|Hey} would you mind {stating|sharing} which blog platform you’re {working with|using}?
    I’m {looking|planning|going} to start my own blog
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    decision|selecting|choosing|deciding} between BlogEngine/Wordpress/B2evolution and Drupal.
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    different then most blogs and I’m looking for something {completely unique|unique}.
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    browsers|browsers} and I must say this blog loads
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    it!|
    {I love|I really like|I like|Everyone loves} it {when people|when
    individuals|when folks|whenever people} {come together|get
    together} and share {opinions|thoughts|views|ideas}.

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    Thank you for the {auspicious|good} writeup. It in fact was a amusement account
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    from you! {By the way|However}, how {can|could} we communicate?|
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    up. The {text|words} in your {content|post|article}
    seem to be running off the screen in {Ie|Internet explorer|Chrome|Firefox|Safari|Opera}.
    I’m not sure if this is a {format|formatting} issue
    or something to do with {web browser|internet browser|browser} compatibility but I {thought|figured} I’d
    post to let you know. The {style and design|design and style|layout|design} look great
    though! Hope you get the {problem|issue} {solved|resolved|fixed} soon.
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    time|a while|some time} now and finally got the {bravery|courage} to go ahead and give you a shout out from {New
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    I’m {bored to tears|bored to death|bored} at work so I decided to {check
    out|browse} your {site|website|blog} on my iphone during
    lunch break. I {enjoy|really like|love} the {knowledge|info|information} you
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    I’m {shocked|amazed|surprised} at how {quick|fast} your blog loaded on my {mobile|cell phone|phone} ..
    I’m not even using WIFI, just 3G .. {Anyhow|Anyways}, {awesome|amazing|very good|superb|good|wonderful|fantastic|excellent|great} {site|blog}!|
    Its {like you|such as you} {read|learn} my {mind|thoughts}!
    You {seem|appear} {to understand|to know|to grasp} {so much|a lot} {approximately|about} this, {like you|such as you} wrote the {book|e-book|guide|ebook|e
    book} in it or something. {I think|I feel|I believe} {that you|that
    you simply|that you just} {could|can} do with {some|a few} {%|p.c.|percent} to {force|pressure|drive|power} the message
    {house|home} {a bit|a little bit}, {however|but} {other than|instead of} that, {this is|that is} {great|wonderful|fantastic|magnificent|excellent} blog.
    {A great|An excellent|A fantastic} read. {I’ll|I will} {definitely|certainly} be back.|
    I visited {multiple|many|several|various} {websites|sites|web sites|web pages|blogs} {but|except|however} the
    audio {quality|feature} for audio songs {current|present|existing}
    at this {website|web site|site|web page}
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    time to time} and i own a similar one and i was just {wondering|curious} if
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    against} it, any plugin or anything you can {advise|suggest|recommend}?
    I get so much lately it’s driving me {mad|insane|crazy} so any {assistance|help|support} is very
    much appreciated.|
    Greetings! {Very helpful|Very useful} advice {within this|in this particular} {article|post}!
    {It is the|It’s the} little changes {that make|which will make|that produce|that will make} {the
    biggest|the largest|the greatest|the most important|the most significant} changes.
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    {I really|I truly|I seriously|I absolutely} love {your blog|your site|your website}..
    {Very nice|Excellent|Pleasant|Great} colors & theme.
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    web site|this amazing site} yourself? Please reply back as I’m
    {looking to|trying to|planning to|wanting to|hoping to|attempting to} create {my own|my very own|my own
    personal} {blog|website|site} and {would like to|want to|would love to} {know|learn|find out} where you got this from or {what the|exactly what the|just what the} theme {is called|is named}.
    {Thanks|Many thanks|Thank you|Cheers|Appreciate it|Kudos}!|
    {Hi there|Hello there|Howdy}! This {post|article|blog post} {couldn’t|could not} be
    written {any better|much better}! {Reading through|Looking at|Going through|Looking
    through} this {post|article} reminds me of my previous roommate!
    He {always|constantly|continually} kept {talking about|preaching about} this.
    {I will|I’ll|I am going to|I most certainly will} {forward|send} {this article|this information|this post} to
    him. {Pretty sure|Fairly certain} {he will|he’ll|he’s going to} {have a good|have a very good|have a great} read.
    {Thank you for|Thanks for|Many thanks for|I appreciate you
    for} sharing!|
    {Wow|Whoa|Incredible|Amazing}! This blog looks {exactly|just} like my old one!
    It’s on a {completely|entirely|totally} different {topic|subject} but it has pretty much the
    same {layout|page layout} and design. {Excellent|Wonderful|Great|Outstanding|Superb} choice of colors!|
    {There is|There’s} {definately|certainly} {a lot to|a great deal
    to} {know about|learn about|find out about} this {subject|topic|issue}.
    {I like|I love|I really like} {all the|all of the} points {you made|you’ve made|you
    have made}.|
    {You made|You’ve made|You have made} some {decent|good|really good} points there.
    I {looked|checked} {on the internet|on the web|on the net} {for more info|for more information|to find out more|to learn
    more|for additional information} about the issue and found {most
    individuals|most people} will go along with your
    views on {this website|this site|this web site}.|
    {Hi|Hello|Hi there|What’s up}, I {log on to|check|read}
    your {new stuff|blogs|blog} {regularly|like every week|daily|on a regular basis}.
    Your {story-telling|writing|humoristic} style is
    {awesome|witty}, keep {doing what you’re doing|up the good work|it up}!|
    I {simply|just} {could not|couldn’t} {leave|depart|go away} your {site|web site|website} {prior to|before} suggesting that I {really|extremely|actually} {enjoyed|loved} {the standard|the usual} {information|info} {a person|an individual} {supply|provide} {for your|on your|in your|to
    your} {visitors|guests}? Is {going to|gonna} be
    {back|again} {frequently|regularly|incessantly|steadily|ceaselessly|often|continuously} {in order to|to}
    {check up on|check out|inspect|investigate cross-check} new posts|
    {I wanted|I needed|I want to|I need to} to thank you for this {great|excellent|fantastic|wonderful|good|very good} read!!
    I {definitely|certainly|absolutely} {enjoyed|loved} every {little bit of|bit of} it.
    {I have|I’ve got|I have got} you {bookmarked|book marked|book-marked|saved as a favorite} {to check out|to look at}
    new {stuff you|things you} post…|
    {Hi|Hello|Hi there|What’s up}, just wanted to {mention|say|tell you}, I
    {enjoyed|liked|loved} this {article|post|blog post}.
    It was {inspiring|funny|practical|helpful}. Keep on posting!|
    I {{leave|drop|{write|create}} a {comment|leave a response}|drop a {comment|leave a response}|{comment|leave a
    response}} {each time|when|whenever} I {appreciate|like|especially enjoy} a {post|article} on a {site|{blog|website}|site|website} or {I have|if
    I have} something to {add|contribute|valuable to contribute} {to
    the discussion|to the conversation}. {It is|Usually it is|Usually it’s|It’s} {a result of|triggered by|caused by} the {passion|fire|sincerness} {communicated|displayed}
    in the {post|article} I {read|looked at|browsed}.
    And {on|after} this {post|article} Amphetamine, Energy Drinks and Associated Problems | Heroin and Cornflakes.
    I {{was|was actually} moved|{was|was actually} excited} enough to
    {drop|{leave|drop|{write|create}}|post} a {thought|{comment|{comment|leave a response}a response}} {:
    -P|:)|;)|;-)|:-)} I {do have|actually do have} {{some|a few} questions|a couple
    of questions|2 questions} for you {if you {don’t|do not|usually
    do not|tend not to} mind|if it’s {allright|okay}}.
    {Is it|Could it be} {just|only|simply} me or {do|does it {seem|appear|give the impression|look|look as if|look like} like} {some|a few} of {the|these} {comments|responses|remarks} {look|appear|come across} {like they are|as if they are|like} {coming from|written by|left by} brain dead {people|visitors|folks|individuals}?
    :-P And, if you are {posting|writing} {on|at} {other|additional} {sites|social sites|online sites|online social sites|places},
    {I’d|I would} like to {follow|keep up with} {you|{anything|everything} {new|fresh}
    you have to post}. {Could|Would} you {list|make a
    list} {all|every one|the complete urls} of {your|all your} {social|communal|community|public|shared} {pages|sites} like your {twitter feed, Facebook page or linkedin profile|linkedin profile, Facebook page or twitter feed|Facebook page, twitter feed, or linkedin
    profile}?|
    {Hi there|Hello}, I enjoy reading {all of|through} your
    {article|post|article post}. I {like|wanted} to write a little
    comment to support you.|
    I {always|constantly|every time} spent my half an hour
    to read this {blog|weblog|webpage|website|web site}’s {articles|posts|articles or reviews|content} {everyday|daily|every day|all the time} along with a {cup|mug} of coffee.|
    I {always|for all time|all the time|constantly|every time} emailed
    this {blog|weblog|webpage|website|web site} post page to
    all my {friends|associates|contacts}, {because|since|as|for the reason that} if like
    to read it {then|after that|next|afterward} my {friends|links|contacts}
    will too.|
    My {coder|programmer|developer} is trying to {persuade|convince} me to
    move to .net from PHP. I have always disliked the idea
    because of the {expenses|costs}. But he’s tryiong none the less.
    I’ve been using {Movable-type|WordPress} on {a number of|a variety of|numerous|several|various} websites for
    about a year and am {nervous|anxious|worried|concerned} about switching to another platform.
    I have heard {fantastic|very good|excellent|great|good} things about blogengine.net.
    Is there a way I can {transfer|import} all my wordpress {content|posts} into it?

    {Any kind of|Any} help would be {really|greatly} appreciated!|
    {Hello|Hi|Hello there|Hi there|Howdy|Good day}!
    I could have sworn I’ve {been to|visited} {this blog|this web site|this website|this site|your blog} before but after {browsing through|going through|looking at} {some of the|a few
    of the|many of the} {posts|articles} I realized it’s new to me.
    {Anyways|Anyhow|Nonetheless|Regardless}, I’m {definitely|certainly} {happy|pleased|delighted} {I
    found|I discovered|I came across|I stumbled upon}
    it and I’ll be {bookmarking|book-marking} it and
    checking back {frequently|regularly|often}!|
    {Terrific|Great|Wonderful} {article|work}! {This is|That
    is} {the type of|the kind of} {information|info} {that are meant to|that are supposed to|that
    should} be shared {around the|across the} {web|internet|net}.
    {Disgrace|Shame} on {the {seek|search} engines|Google} for
    {now not|not|no longer} positioning this {post|submit|publish|put
    up} {upper|higher}! Come on over and {talk over with|discuss with|seek advice from|visit|consult
    with} my {site|web site|website} . {Thank you|Thanks}
    =)|
    Heya {i’m|i am} for the first time here. I {came across|found} this board and I find It {truly|really} useful
    & it helped me out {a lot|much}. I hope to give something back and {help|aid} others like you {helped|aided} me.|
    {Hi|Hello|Hi there|Hello there|Howdy|Greetings}, {I think|I
    believe|I do believe|I do think|There’s no doubt that}
    {your site|your website|your web site|your blog} {might be|may
    be|could be|could possibly be} having {browser|internet browser|web browser} compatibility
    {issues|problems}. {When I|Whenever I} {look at your|take a look at your} {website|web site|site|blog} in Safari, it
    looks fine {but when|however when|however, if|however, when} opening in {Internet
    Explorer|IE|I.E.}, {it has|it’s got} some overlapping issues.
    {I just|I simply|I merely} wanted to {give you a|provide you with a}
    quick heads up! {Other than that|Apart from that|Besides that|Aside from that},
    {fantastic|wonderful|great|excellent} {blog|website|site}!|
    {A person|Someone|Somebody} {necessarily|essentially} {lend a hand|help|assist}
    to make {seriously|critically|significantly|severely} {articles|posts} {I would|I might|I’d}
    state. {This is|That is} the {first|very first} time I
    frequented your {web page|website page} and {to this point|so far|thus far|up to now}?

    I {amazed|surprised} with the {research|analysis} you made to
    {create|make} {this actual|this particular} {post|submit|publish|put
    up} {incredible|amazing|extraordinary}. {Great|Wonderful|Fantastic|Magnificent|Excellent} {task|process|activity|job}!|
    Heya {i’m|i am} for {the primary|the first} time here.
    I {came across|found} this board and I {in finding|find|to find} It {truly|really} {useful|helpful} & it helped me out {a lot|much}.
    {I am hoping|I hope|I’m hoping} {to give|to
    offer|to provide|to present} {something|one thing}
    {back|again} and {help|aid} others {like you|such as you} {helped|aided}
    me.|
    {Hello|Hi|Hello there|Hi there|Howdy|Good day|Hey
    there}! {I just|I simply} {would like to|want to|wish to}
    {give you a|offer you a} {huge|big} thumbs up {for the|for your} {great|excellent} {info|information} {you have|you’ve got|you have got} {here|right
    here} on this post. {I will be|I’ll be|I am} {coming back to|returning to} {your blog|your site|your website|your web site} for more soon.|
    I {always|all the time|every time} used to {read|study} {article|post|piece of writing|paragraph} in news papers but now as I am a user of {internet|web|net} {so|thus|therefore} from now I am using net for {articles|posts|articles or
    reviews|content}, thanks to web.|
    Your {way|method|means|mode} of {describing|explaining|telling} {everything|all|the whole thing} in this {article|post|piece of writing|paragraph} is {really|actually|in fact|truly|genuinely} {nice|pleasant|good|fastidious}, {all|every
    one} {can|be able to|be capable of} {easily|without difficulty|effortlessly|simply} {understand|know|be aware of}
    it, Thanks a lot.|
    {Hi|Hello} there, {I found|I discovered} your {blog|website|web site|site} {by means of|via|by the use
    of|by way of} Google {at the same time as|whilst|even as|while}
    {searching for|looking for} a {similar|comparable|related} {topic|matter|subject}, your
    {site|web site|website} {got here|came} up, it {looks|appears|seems|seems to be|appears to be like} {good|great}.
    {I have|I’ve} bookmarked it in my google bookmarks.

    {Hello|Hi} there, {simply|just} {turned into|became|was|become|changed into} {aware of|alert to}
    your {blog|weblog} {thru|through|via} Google, {and found|and located} that {it is|it’s} {really|truly} informative.
    {I’m|I am} {gonna|going to} {watch out|be careful} for brussels.
    {I will|I’ll} {appreciate|be grateful} {if you|should you|when you|in the event you|in case
    you|for those who|if you happen to} {continue|proceed} this {in future}.
    {A lot of|Lots of|Many|Numerous} {other folks|folks|other people|people} {will be|shall be|might be|will probably be|can be|will likely be} benefited {from your|out of your} writing.
    Cheers!|
    {I am|I’m} curious to find out what blog {system|platform} {you have been|you
    happen to be|you are|you’re} {working with|utilizing|using}?
    I’m {experiencing|having} some {minor|small} security {problems|issues} with my latest
    {site|website|blog} and {I would|I’d} like to find something more {safe|risk-free|safeguarded|secure}.
    Do you have any {solutions|suggestions|recommendations}?|
    {I am|I’m} {extremely|really} impressed with your writing skills
    {and also|as well as} with the layout on your {blog|weblog}.
    Is this a paid theme or did you {customize|modify} it yourself?
    {Either way|Anyway} keep up the {nice|excellent} quality writing, {it’s|it is} rare to see a {nice|great} blog like this one {these days|nowadays|today}.|
    {I am|I’m} {extremely|really} {inspired|impressed} {with your|together with your|along with your} writing {talents|skills|abilities} {and also|as {smartly|well|neatly}
    as} with the {layout|format|structure} {for your|on your|in your|to your} {blog|weblog}.

    {Is this|Is that this} a paid {subject|topic|subject matter|theme} or did you {customize|modify} it
    {yourself|your self}? {Either way|Anyway} {stay|keep} up the {nice|excellent} {quality|high quality} writing, {it’s|it is} {rare|uncommon} {to peer|to see|to look} a
    {nice|great} {blog|weblog} like this one {these days|nowadays|today}..|
    {Hi|Hello}, Neat post. {There is|There’s} {a problem|an issue} {with your|together with your|along with your} {site|web site|website} in {internet|web}
    explorer, {may|might|could|would} {check|test} this?
    IE {still|nonetheless} is the {marketplace|market} {leader|chief} and {a large|a good|a big|a huge} {part of|section
    of|component to|portion of|component of|element of} {other folks|folks|other people|people} will {leave out|omit|miss|pass over} your
    {great|wonderful|fantastic|magnificent|excellent} writing {due to|because of} this problem.|
    {I’m|I am} not sure where {you are|you’re} getting your {info|information}, but
    {good|great} topic. I needs to spend some time learning {more|much more} or understanding more.
    Thanks for {great|wonderful|fantastic|magnificent|excellent}
    {information|info} I was looking for this {information|info} for my mission.|
    {Hi|Hello}, i think that i saw you visited my {blog|weblog|website|web site|site} {so|thus} i came
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