Scientists identify pomegranate juice components that could stop cancer from spreading

pomegranate and cancerRIVERSIDE, Calif. – Researchers at the University of California, Riverside have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone. The research could lead to new therapies for preventing cancer metastasis.

Performed in the lab of Manuela Martins-Green, a professor of cell biology, the research was presented today (Dec. 12, 2010) at the 50th annual meeting of the American Society for Cell Biology taking place in Philadelphia.

Prostate cancer is the second-leading cause of cancer-related deaths in men in the United States. To date, there is no cure for it. If prostate cancer recurs after treatments of surgery and/or radiation, usually the next treatment is the suppression of the male hormone testosterone, which inhibits the growth of the cancer cells because they need this hormone to grow. But over time, the cancer develops ways to resist hormone suppression therapies, becomes very aggressive, and metastasizes to the bone marrow, lungs, and lymph nodes, usually resulting in the patient’s death.

The Martins-Green lab applied pomegranate juice on laboratory-cultured prostate cancer cells that were resistant to testosterone (the more resistant a cancer cell is to testosterone, the more prone it is to metastasizing).

The researchers – Martins-Green, graduate student Lei Wang and undergraduate students Andre Alcon and Jeffrey Ho – found that the pomegranate juice-treated tumor cells that had not died with the treatment showed increased cell adhesion (meaning fewer cells breaking away) and decreased cell migration.

Next, the researchers identified the following active groups of ingredients in pomegranate juice that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells: phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids.

“Having identified them, we can now modify cancer-inhibiting components in pomegranate juice to improve their functions and make them more effective in preventing prostate cancer metastasis, leading to more effective drug therapies,” Martins-Green said.

“Because the genes and proteins involved in the movement of prostate cancer cells are essentially the same as those involved in the movement of other types of cancer cells, the same modified components of the juice could have a much broader impact in cancer treatment.”

Martins-Green explained that an important protein produced in the bone marrow causes the cancer cells to move to the bone where they can then form new tumors.

“We show that pomegranate juice markedly inhibits the function of this protein, and thus this juice has the potential of preventing metastasis of the prostate cancer cells to the bone,” she said.

Next, her lab plans to do additional tests in an in vivo model for prostate cancer metastasis to determine whether the same cancer-inhibiting components that work in cultured cells can prevent metastasis without side effects.

###

Traditional herbal medicine in Far west NepalTraditional Herbal Medicine in Far-West Nepal

Traditional Chinese Medicine

44 comments for “Scientists identify pomegranate juice components that could stop cancer from spreading

  1. Olive Oil
    October 4, 2011 at 10:30 am

    You have noted very interesting details ! ps decent website .

  2. May 28, 2012 at 9:23 pm

    Hi, Neat postThere is an issue using your site in web explorer, could test this IE nonetheless is the marketplace chief as well as a large a part of individuals will miss your great writing for that reason problem.

  3. May 31, 2012 at 7:00 am

    Hi there to all, how is all, I think every one is getting more from this website, and your views are nice in support of new users.

  4. June 1, 2012 at 4:27 am

    An engrossing communicating is developer note. I cogitate that you should pen solon about this message, it power not certainly be a inhibition discipline but typically grouping aren’t sufficiency for you to speak on such matters. To the succeeding. Cheers similar to your Khmer Karaoke Superstars.

  5. June 11, 2012 at 10:13 am

    It’s a real nice and also useful part of information. I are glad that you just shared this particular useful information around. Please retain us updated like this. Thanks for sharing.

  6. June 24, 2012 at 2:10 am

    After research a number of of the weblog posts in your web site now, and I really like your manner of blogging. I bookmarked it to my bookmark web site list and might be checking back soon. Pls check out my web site as nicely and let me know what you think.

  7. June 26, 2012 at 7:48 am

    Appreciate it for helping out, superb information. “The health of nations is more important than the wealth of nations.” by Will Durant.

  8. July 1, 2012 at 6:59 am

    Iím not that much of a internet reader to be honest but your blogs really nice, keep it up! I’ll go ahead and bookmark your website to come back later on. Many thanks by Minnie17b

  9. November 26, 2013 at 1:53 pm

    The website can also handle any disagreements that might crop
    up. Just like you would have done a study of the different car models before selecting
    one, you would need to understand the basic car finance model and how it is offered using the
    car finance calculator to consumers. You cannot create a realistic business
    plan without evaluating how well your financial strategies are working.

  10. November 27, 2013 at 7:20 pm

    There are several methods and tools available for creating,
    using and adjusting a personal budget. Excel is an
    application that’s familiar to all of us, and you can easily find free templates, including some that specifically forecast your financial future.

    Usually, different financial structure exists in
    the capital market.

  11. November 28, 2013 at 12:03 pm

    very few internet websites that occur to become in depth beneath, from our point of view are undoubtedly properly worth checking out

  12. November 29, 2013 at 5:37 pm

    Every once in a when we pick out blogs that we study. Listed below would be the most up-to-date sites that we decide on.

  13. November 29, 2013 at 11:24 pm

    This article will assist the internet users for setting
    up new webpage or even a blog from start to end.

  14. December 1, 2013 at 8:47 pm

    we came across a cool web site that you simply may well appreciate. Take a appear in the event you want

  15. December 1, 2013 at 10:29 pm

    Wonderful story, reckoned we could combine a handful of unrelated data, nonetheless actually really worth taking a appear, whoa did a single find out about Mid East has got more problerms as well

  16. December 2, 2013 at 3:51 am

    Every as soon as inside a when we select blogs that we read. Listed beneath are the most current websites that we select

  17. September 11, 2014 at 9:04 am

    I really like looking through an artice that will makme people
    think. Also, many thanks for allowing me to comment!

  18. September 13, 2014 at 4:40 pm

    So stunning! I really like the earthy & classic tones of the wedding! I’m so stealing the succulent idea. Wonderful bride, handsome hubby & bridal party. Wonderful photographs as always Tammy!

  19. September 15, 2014 at 9:16 pm

    I often thought it is best to go that has a pop of color in your bouquet. But,following seeing some bouquets that just pick up a shade of color of your dress, I am definitely beginning to lean towards that trend. So really!

  20. September 16, 2014 at 2:03 pm

    Greate pieces. Keep posting such kind of info on your
    page. Im really impressed by your blog.
    Hey there, You have performed an incredible job. I will certainly digg it and
    in my view recommend to my friends. I’m sure they’ll be benefited from this site.

  21. September 17, 2014 at 2:39 am

    I love you.

  22. September 17, 2014 at 6:06 am

    These types of layout definitely decreases out the reduction of silver but unnecessarily prolongs the
    whole video gaming procedure. Clearing and building would never ever
    getting a problem in Dragon town they are conceivable since longer as you
    have actually sufficient gold. Marvel Masterworks: Silver Surfer Volume 2 TP (DM Variant Edition).

  23. September 18, 2014 at 5:42 am

    Greetings I amm so glad I found your website, I reallpy found you
    bby mistake, while I waas researching on Digg
    for something else, Nohetheless I am here now
    and would just like to say cheers for a incredible post and a all round interesting blog (I also love the theme/design), I don’t have time to browse it all at the minute but I have book-marked it
    and also added in your RSS feeds, so when I have time I will
    bbe back to read a lot more, Please do keep up the excellent
    b.

  24. September 18, 2014 at 2:23 pm

    Hello i am kavin,its my first time tto commenting anywhere, when i read this paragraph i thought i could also make comment
    due too this good post.

  25. September 18, 2014 at 3:28 pm

    I would like to express my thanks to this writer just for bailing me out of this instance. Just after searching throughout the the net and meeting tricks that were not helpful, I believed my life was gone. Existing without the solutions to the problems you have solved through your good write-up is a critical case, and those that could have badly damaged my entire career if I hadn’t noticed your web site. Your own understanding and kindness in touching all the things was invaluable. I’m not sure what I would’ve done if I hadn’t encountered such a stuff like this. I can at this time look ahead to my future. Thanks a lot very much for the impressive and effective help. I won’t be reluctant to recommend your web site to anyone who would like tips about this problem.

  26. September 18, 2014 at 6:17 pm

    If you are going for most excellent contents like myself, simply visit this
    web site every day for the reason that it offers feature contents,
    thanks

  27. September 19, 2014 at 6:56 am

    I always emailed this weblog post page to all my associates, as if like to read it afterward my
    contacts will too.

  28. September 19, 2014 at 2:18 pm

    David, you don’t receive copies of your previous letters. As the letters go forward that selection can be in the hundreds. But if there’s a particular letter send us an email and maybe we can figure something out.

  29. September 20, 2014 at 3:02 am

    Good web site you’ve got here.. It’s hard to find high-quality writing like yours nowadays.

    I honestly appreciate people like you! Take care!!

  30. September 20, 2014 at 5:39 am

    Welcome to Studio Plazma, Visit us on:

  31. September 20, 2014 at 7:34 am

    I simply want to tell you that I am all new to blogs and truly loved this web blog. Most likely I’m want to bookmark your website . You absolutely come with great stories. Thanks a bunch for sharing your website.

  32. September 21, 2014 at 4:07 am

    Woah! I’m really digging the template/theme of this site.
    It’s simple, yet effective. A lot of times it’s very difficult to get that
    “perfect balance” between usability and visual appearance.
    I must say you have done a excellent job with this.
    Additionally, the blog loads extremely fast for me on Chrome.
    Outstanding Blog!

  33. September 21, 2014 at 5:49 am

    What’s up to every , since I am truly eager of reading this web site’s post to be updated daily.
    It includes good material.

  34. September 21, 2014 at 1:59 pm

    My dream retirement would be no bills, no worries and fantastic health.

  35. September 21, 2014 at 3:44 pm
  36. September 21, 2014 at 9:25 pm

    own my own radio station

  37. September 22, 2014 at 1:05 am

    I quite like reading through a post that can make people think.
    Also, many thanks for allowing me to comment!

  38. September 22, 2014 at 2:14 am
  39. September 22, 2014 at 5:52 am
  40. September 22, 2014 at 7:30 am
  41. September 22, 2014 at 9:26 am

    Thank you for another fantastic article. Where else could anybody get that type of information in such a perfect way of writing? I have a presentation next week, and I am on the look for such information.

  42. September 22, 2014 at 11:51 am
  43. September 22, 2014 at 1:22 pm

    Thanks a lot for the blog post.Much thanks again. Much obliged.

  44. September 22, 2014 at 2:15 pm

Leave a Reply

Your email address will not be published. Required fields are marked *