Scientists identify pomegranate juice components that could stop cancer from spreading

pomegranate and cancerRIVERSIDE, Calif. – Researchers at the University of California, Riverside have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone. The research could lead to new therapies for preventing cancer metastasis.

Performed in the lab of Manuela Martins-Green, a professor of cell biology, the research was presented today (Dec. 12, 2010) at the 50th annual meeting of the American Society for Cell Biology taking place in Philadelphia.

Prostate cancer is the second-leading cause of cancer-related deaths in men in the United States. To date, there is no cure for it. If prostate cancer recurs after treatments of surgery and/or radiation, usually the next treatment is the suppression of the male hormone testosterone, which inhibits the growth of the cancer cells because they need this hormone to grow. But over time, the cancer develops ways to resist hormone suppression therapies, becomes very aggressive, and metastasizes to the bone marrow, lungs, and lymph nodes, usually resulting in the patient’s death.

The Martins-Green lab applied pomegranate juice on laboratory-cultured prostate cancer cells that were resistant to testosterone (the more resistant a cancer cell is to testosterone, the more prone it is to metastasizing).

The researchers – Martins-Green, graduate student Lei Wang and undergraduate students Andre Alcon and Jeffrey Ho – found that the pomegranate juice-treated tumor cells that had not died with the treatment showed increased cell adhesion (meaning fewer cells breaking away) and decreased cell migration.

Next, the researchers identified the following active groups of ingredients in pomegranate juice that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells: phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids.

“Having identified them, we can now modify cancer-inhibiting components in pomegranate juice to improve their functions and make them more effective in preventing prostate cancer metastasis, leading to more effective drug therapies,” Martins-Green said.

“Because the genes and proteins involved in the movement of prostate cancer cells are essentially the same as those involved in the movement of other types of cancer cells, the same modified components of the juice could have a much broader impact in cancer treatment.”

Martins-Green explained that an important protein produced in the bone marrow causes the cancer cells to move to the bone where they can then form new tumors.

“We show that pomegranate juice markedly inhibits the function of this protein, and thus this juice has the potential of preventing metastasis of the prostate cancer cells to the bone,” she said.

Next, her lab plans to do additional tests in an in vivo model for prostate cancer metastasis to determine whether the same cancer-inhibiting components that work in cultured cells can prevent metastasis without side effects.


Traditional herbal medicine in Far west NepalTraditional Herbal Medicine in Far-West Nepal

Traditional Chinese Medicine

106 comments for “Scientists identify pomegranate juice components that could stop cancer from spreading

  1. Olive Oil
    October 4, 2011 at 10:30 am

    You have noted very interesting details ! ps decent website .

  2. May 28, 2012 at 9:23 pm

    Hi, Neat postThere is an issue using your site in web explorer, could test this IE nonetheless is the marketplace chief as well as a large a part of individuals will miss your great writing for that reason problem.

  3. May 31, 2012 at 7:00 am

    Hi there to all, how is all, I think every one is getting more from this website, and your views are nice in support of new users.

  4. June 1, 2012 at 4:27 am

    An engrossing communicating is developer note. I cogitate that you should pen solon about this message, it power not certainly be a inhibition discipline but typically grouping aren’t sufficiency for you to speak on such matters. To the succeeding. Cheers similar to your Khmer Karaoke Superstars.

  5. June 11, 2012 at 10:13 am

    It’s a real nice and also useful part of information. I are glad that you just shared this particular useful information around. Please retain us updated like this. Thanks for sharing.

  6. June 24, 2012 at 2:10 am

    After research a number of of the weblog posts in your web site now, and I really like your manner of blogging. I bookmarked it to my bookmark web site list and might be checking back soon. Pls check out my web site as nicely and let me know what you think.

  7. June 26, 2012 at 7:48 am

    Appreciate it for helping out, superb information. “The health of nations is more important than the wealth of nations.” by Will Durant.

  8. July 1, 2012 at 6:59 am

    Iím not that much of a internet reader to be honest but your blogs really nice, keep it up! I’ll go ahead and bookmark your website to come back later on. Many thanks by Minnie17b

  9. November 26, 2013 at 1:53 pm

    The website can also handle any disagreements that might crop
    up. Just like you would have done a study of the different car models before selecting
    one, you would need to understand the basic car finance model and how it is offered using the
    car finance calculator to consumers. You cannot create a realistic business
    plan without evaluating how well your financial strategies are working.

  10. November 27, 2013 at 7:20 pm

    There are several methods and tools available for creating,
    using and adjusting a personal budget. Excel is an
    application that’s familiar to all of us, and you can easily find free templates, including some that specifically forecast your financial future.

    Usually, different financial structure exists in
    the capital market.

  11. November 28, 2013 at 12:03 pm

    very few internet websites that occur to become in depth beneath, from our point of view are undoubtedly properly worth checking out

  12. November 29, 2013 at 5:37 pm

    Every once in a when we pick out blogs that we study. Listed below would be the most up-to-date sites that we decide on.

  13. November 29, 2013 at 11:24 pm

    This article will assist the internet users for setting
    up new webpage or even a blog from start to end.

  14. December 1, 2013 at 8:47 pm

    we came across a cool web site that you simply may well appreciate. Take a appear in the event you want

  15. December 1, 2013 at 10:29 pm

    Wonderful story, reckoned we could combine a handful of unrelated data, nonetheless actually really worth taking a appear, whoa did a single find out about Mid East has got more problerms as well

  16. December 2, 2013 at 3:51 am

    Every as soon as inside a when we select blogs that we read. Listed beneath are the most current websites that we select

  17. September 11, 2014 at 9:04 am

    I really like looking through an artice that will makme people
    think. Also, many thanks for allowing me to comment!

  18. September 13, 2014 at 4:40 pm

    So stunning! I really like the earthy & classic tones of the wedding! I’m so stealing the succulent idea. Wonderful bride, handsome hubby & bridal party. Wonderful photographs as always Tammy!

  19. September 15, 2014 at 9:16 pm

    I often thought it is best to go that has a pop of color in your bouquet. But,following seeing some bouquets that just pick up a shade of color of your dress, I am definitely beginning to lean towards that trend. So really!

  20. September 16, 2014 at 2:03 pm

    Greate pieces. Keep posting such kind of info on your
    page. Im really impressed by your blog.
    Hey there, You have performed an incredible job. I will certainly digg it and
    in my view recommend to my friends. I’m sure they’ll be benefited from this site.

  21. September 17, 2014 at 2:39 am

    I love you.

  22. September 17, 2014 at 6:06 am

    These types of layout definitely decreases out the reduction of silver but unnecessarily prolongs the
    whole video gaming procedure. Clearing and building would never ever
    getting a problem in Dragon town they are conceivable since longer as you
    have actually sufficient gold. Marvel Masterworks: Silver Surfer Volume 2 TP (DM Variant Edition).

  23. September 18, 2014 at 5:42 am

    Greetings I amm so glad I found your website, I reallpy found you
    bby mistake, while I waas researching on Digg
    for something else, Nohetheless I am here now
    and would just like to say cheers for a incredible post and a all round interesting blog (I also love the theme/design), I don’t have time to browse it all at the minute but I have book-marked it
    and also added in your RSS feeds, so when I have time I will
    bbe back to read a lot more, Please do keep up the excellent

  24. September 18, 2014 at 2:23 pm

    Hello i am kavin,its my first time tto commenting anywhere, when i read this paragraph i thought i could also make comment
    due too this good post.

  25. September 18, 2014 at 3:28 pm

    I would like to express my thanks to this writer just for bailing me out of this instance. Just after searching throughout the the net and meeting tricks that were not helpful, I believed my life was gone. Existing without the solutions to the problems you have solved through your good write-up is a critical case, and those that could have badly damaged my entire career if I hadn’t noticed your web site. Your own understanding and kindness in touching all the things was invaluable. I’m not sure what I would’ve done if I hadn’t encountered such a stuff like this. I can at this time look ahead to my future. Thanks a lot very much for the impressive and effective help. I won’t be reluctant to recommend your web site to anyone who would like tips about this problem.

  26. September 18, 2014 at 6:17 pm

    If you are going for most excellent contents like myself, simply visit this
    web site every day for the reason that it offers feature contents,

  27. September 19, 2014 at 6:56 am

    I always emailed this weblog post page to all my associates, as if like to read it afterward my
    contacts will too.

  28. September 19, 2014 at 2:18 pm

    David, you don’t receive copies of your previous letters. As the letters go forward that selection can be in the hundreds. But if there’s a particular letter send us an email and maybe we can figure something out.

  29. September 20, 2014 at 3:02 am

    Good web site you’ve got here.. It’s hard to find high-quality writing like yours nowadays.

    I honestly appreciate people like you! Take care!!

  30. September 20, 2014 at 5:39 am

    Welcome to Studio Plazma, Visit us on:

  31. September 20, 2014 at 7:34 am

    I simply want to tell you that I am all new to blogs and truly loved this web blog. Most likely I’m want to bookmark your website . You absolutely come with great stories. Thanks a bunch for sharing your website.

  32. September 21, 2014 at 4:07 am

    Woah! I’m really digging the template/theme of this site.
    It’s simple, yet effective. A lot of times it’s very difficult to get that
    “perfect balance” between usability and visual appearance.
    I must say you have done a excellent job with this.
    Additionally, the blog loads extremely fast for me on Chrome.
    Outstanding Blog!

  33. September 21, 2014 at 5:49 am

    What’s up to every , since I am truly eager of reading this web site’s post to be updated daily.
    It includes good material.

  34. September 21, 2014 at 1:59 pm

    My dream retirement would be no bills, no worries and fantastic health.

  35. September 21, 2014 at 3:44 pm
  36. September 21, 2014 at 9:25 pm

    own my own radio station

  37. September 22, 2014 at 1:05 am

    I quite like reading through a post that can make people think.
    Also, many thanks for allowing me to comment!

  38. September 22, 2014 at 2:14 am
  39. September 22, 2014 at 5:52 am
  40. September 22, 2014 at 7:30 am
  41. September 22, 2014 at 9:26 am

    Thank you for another fantastic article. Where else could anybody get that type of information in such a perfect way of writing? I have a presentation next week, and I am on the look for such information.

  42. September 22, 2014 at 11:51 am
  43. September 22, 2014 at 1:22 pm

    Thanks a lot for the blog post.Much thanks again. Much obliged.

  44. September 22, 2014 at 2:15 pm
  45. September 22, 2014 at 7:47 pm

    You have remarked very interesting details! ps nice web site.

  46. September 23, 2014 at 2:00 am

    Magnificent beat ! I wish to apprentice while you amend your site, how could i subscribe for a blog website? The account helped me a acceptable deal. I had been tiny bit acquainted of this your broadcast provided bright clear concept

  47. September 23, 2014 at 11:26 am

    An impressive share! I’ve just forwarded this onto a coworker who
    was conducting a little homework onn this. And he actually bought me lunch due to the fact
    that I stumbled upon it for him… lol. So let mee reword this….
    Thanks for the meal!! But yeah, thanxx for spending some time
    to diecuss this issue here on your internet site.

  48. September 23, 2014 at 4:08 pm
  49. September 23, 2014 at 7:09 pm

    I do think this web web-site has acquired some pretty superb information for everyone . “Years wrinkle the skin, but to present up enthusiasm wrinkles the soul.” by Samuel Ullman.

  50. September 23, 2014 at 9:51 pm
  51. September 24, 2014 at 1:09 am

    I think this is among the most significant information for me.And i’m glad reading your article. But want to remark on few general things, The web site style is great, the articles is really nice : D. Good job, cheers

  52. September 24, 2014 at 7:47 am

    coach bagsLove coach bags this bag! Tons of room and pockets, it’s little bit heavy.
    Cheap Michael Kors Purses

  53. September 24, 2014 at 3:49 pm
  54. September 24, 2014 at 5:36 pm

    It is really a nice and helpful piece of information. I

  55. September 24, 2014 at 6:03 pm

    The State inspection report notes that Bright Start teachers were not following a policy of using written attendance sheets because it was Christmas Eve.

  56. September 25, 2014 at 10:44 am

    how do you resist those strong temptations to eat wrong foods and
    hurt your health and your light level. Gluten is the
    protein commonly found in Barley, Wheat and
    Rye. Instead of focusing on a futuristic goal such as losing 10 pounds, focus on what you
    are doing every day to become healthier.

  57. September 25, 2014 at 11:03 am

    After study many of the content on your own internet site now, and I genuinely like your means of blogging. I bookmarked it to my bookmark internet site list and you will be checking back soon. Pls check out my site also and make me aware what you think.

  58. September 25, 2014 at 11:26 am

    The importance of home improvement loans cannot be over emphasized. Luckily for many home owners, there are government and private sponsored loans that they can take advantage of!

  59. September 25, 2014 at 11:43 am

    It’s genuinely very complicated in this busy life to listen news on Television, therefore I just use web for that purpose, and obtain the latest news.

  60. September 25, 2014 at 11:57 am

    You can get 1000′s brand names along with each one of these could be costing an incredible level michael kors apple iphone 5.You can get kinds of engagement make-up offering lightweight constitute plus hefty comprise michael kors mens watches macys researching on printing options – do not forget to research though on your printing options. It again maintains this campfire the fact that Aries commenced consumption michael kors tote black this suggests picking words precisely which were short but extremely informative. Astrology will let you realize when ever these kinds of time frame eyeglass frames are actually, set up compatibility around an individual along with your mate is certainly tough a sufficient amount of to help you or perhaps a astrological aspects, together with your skill for you to admiration typically the shift essential through inside utes authorities was overturned because of a court ruling to the grounds that typically the ban on use of logos and imagery can be a violation of cigarette companies’ rights. However , , customer happiness complicated wish to have really enjoy together with respect they will are likely to tumble easily regarding flattery, specially while using martial arts michael kors hamilton specchio while handful of them are weaved, others come at a knit form like other styles of briefs for the purpose of men. Michael Kors Boots On Sale A person have a tendency to overdo important things for you, specifically linked to your own swimsuit.

  61. September 25, 2014 at 5:29 pm

    Magnificent website. Plenty of useful info here. I

  62. September 25, 2014 at 7:29 pm

    Also, if you could make your own map pack consisting of 4 maps from any of
    the titles, what would they be. High levels have epic guns,
    low levels have crappy guns. The game automatically comes with one map known as Kino Der

  63. September 26, 2014 at 3:08 am

    coach bags
    Coach Handbags Outlet

  64. September 26, 2014 at 10:00 pm

    Without delays, you could apply for One year loans
    absolutely no credit check that is specifically created for making it possible for bad credit revenue
    seekers that happen to be in need of supplemental income help On the other hand, should
    you not want to publish collateral in exchange for the amount
    you borrow, you can try to find unsecured
    personal loans for bad credit The original best flexible mortgage rates usually are
    well below the existing existing best adaptable mortgage rates charged during next years already in the market All
    of these selections should be made early, some of them during your child’s junior year in highschool Do not purchase a great
    grandfather clock if you have no way involving transporting this after the buy To uncover best payday cash advances, 3 month payday advance advice it
    is advisable to visit You could be additional flexible with all your budget simply by looking for ways to increase your
    income by way of having double jobs or maybe working more and more For the homeowners, the actual secured bank loan is reputable option this carries several advantages This applies to other documents likewise, and you should be aware of the consequences Maybe
    you want to eat wintry pizza taking pleasure in and soft ice cream for lunch’who cares’there is no right or wrong Using discounted loans lenders take out the interest payment with the principal in order to get the benefits very first Whatever are the reason, a need
    for cash may perhaps arise abruptly late or maybe skipped bills
    or defaults can go with this personal loan facility in addition to bid farewell
    to unpredicted troubles Rooting your HTC Inspire supply you with a
    lot of rewards or a wide range of heartache Best mortgage loan deals seem
    to be the call of every website, art print ad, television commercial
    along with radio headline Because this is among the wisest methods to earn money possibly at the same time continue to keep
    something which we all call It’s not a problem still Because they generally want no credit score assessment,
    these types of ‘tokens’ are good for individuals with no or maybe little credit standing You’ll likely perhaps you’ve approved, and
    you will then definitely furthermore realize the interest rates tend to be than sensible In this
    section, state the particular party exactly who the accepted offer really should be delivered unique you and
    also it is your realtor All you need to do is
    use your imagination; apply a no work; have a minor patience; and you will be able to experience the benefits
    of having the same types of foods that a lot of people who have greater incomes are capable of

  65. September 27, 2014 at 12:43 am

    Exceptional post however , I was wondering if you could write a litte more on this topic? I’d be very thankful if you could elaborate a little bit more. Appreciate it!

  66. September 27, 2014 at 11:13 am
  67. September 27, 2014 at 5:33 pm

    The State inspection report notes that Bright Start teachers were not following a policy of using written attendance sheets because it was Christmas Eve.

  68. September 28, 2014 at 2:43 am

    A daily enterprise is more than likely to both have simply the big dimension, which is able to maintain 30-40 cubic yards of waste or many smaller
    dimensions, comparable to 6, 9, and 12 cubic yard containers.

  69. September 28, 2014 at 11:50 am

    Somebody essentially assist to make significantly articles I would state. That is the first time I frequented your web page and to this point? I surprised with the research you made to create this particular submit amazing. Fantastic task!

  70. September 28, 2014 at 12:13 pm

    hi!,I love your writing so a lot! share we keep in touch more approximately your post on AOL? I need a specialist in this space to solve my problem. Maybe that is you! Having a look ahead to look you.

  71. September 28, 2014 at 1:58 pm

    After I initially commented I appear to have clicked the -Notify me when new comments are added- checkbox and now whenever a comment is added I receive four emails with the same comment. Perhaps there is an easy method you can remove me from that service? Thank you!

  72. September 28, 2014 at 2:00 pm

    This is a very good post! I admire the way you shared this topic! Keep it up a good job! credit report and score

  73. September 28, 2014 at 6:35 pm

    Convenient Products Of Chicago Long Distance Mover – Insights at::- CHICAGO Long Distance Moving

  74. September 28, 2014 at 7:17 pm

    Very good blog you have here but I was wondering if you knew of any community forums that cover the same topics talked about in this article?I’d really love to be a part of online community where I can get feed-back from other experienced people that share the same interest. If you have any suggestions, please let me know. Appreciate it!

  75. September 28, 2014 at 7:41 pm

    This is a very good post! I admire the way you shared this topic! Keep it up a good job! credit report and score

  76. September 28, 2014 at 8:49 pm

    You made some good points there. I looked on the internet to find out more about the issue and found most individuals will go along with your views on this website.

  77. September 29, 2014 at 7:51 am
  78. September 29, 2014 at 7:53 am
  79. September 29, 2014 at 7:53 am
  80. September 29, 2014 at 7:59 am

    We are a group of volunteers and starting a new scheme in our community. Your web site offered us with valuable info to work on. You’ve done a formidable job and our whole community will be grateful to you.

  81. September 29, 2014 at 5:26 pm

    This site is one of the best I have found.

  82. September 29, 2014 at 8:16 pm

    I agree, for the most part, but don’t you feel as if the issue is more complex than that?

  83. September 29, 2014 at 10:02 pm

    As a Newbie, I am always searching online for articles that can help me. Thank you

  84. September 30, 2014 at 1:14 am


  85. September 30, 2014 at 1:14 am

    Received item fast..smooth transaction

  86. September 30, 2014 at 1:15 am

    Great prices, super fast shipping! Thanks!

  87. Pingback:
  88. September 30, 2014 at 4:23 pm
  89. September 30, 2014 at 4:25 pm
  90. September 30, 2014 at 5:32 pm

    After looking into a handful of the blog articles on your web site, I seriously like your technique of writing a blog. I saved it to my bookmark webpage list and will be checking back in the near future. Please visit my website too and tell me what you think.

  91. September 30, 2014 at 6:55 pm

    I all the time used to read paragraph in news papers but now as I am a user of web thus from now I am using net for posts, thanks to web.

  92. September 30, 2014 at 10:55 pm

    I used to be wondering when you at any time considered changing the layout of your website? Its really nicely published; I really like what youve received to state. But possibly you might a little bit much more from the way of information so men and women could connect with it superior. Youve acquired an awful lot of text for only acquiring just one or two images. Perhaps you could room it out superior?

  93. October 1, 2014 at 7:16 am
  94. October 1, 2014 at 7:23 am

    Compared – Critical Criteria In Chicago Long Distance Mover at:^:- Long Distance Moving Companies in Chicago

  95. October 1, 2014 at 8:47 am

    Oh my goodness! a fantastic post dude. Thanks Nevertheless My business is experiencing concern with ur rss . Don’t know why Not able to sign up for it. Possibly there is any person obtaining identical rss difficulty? Anyone who knows kindly respond. Thnkx

  96. October 1, 2014 at 9:16 am

    You actually make it seem really easy together with your presentation but I find this topic to be actually something that I feel I might by no means understand. It seems too complex and very huge for me. I am having a look forward on your subsequent publish, I will try to get the grasp of it!

  97. October 1, 2014 at 1:19 pm

Leave a Reply

Your email address will not be published. Required fields are marked *