Alcohol and Cancer

• There is sufficient evidence in humans for the carcinogenicity of alcoholic beverages.

• The occurrence of malignant tumors of the oral cavity, pharynx, larynx, esophagus, liver, female breast and colorectum is causally related to the consumption of alcoholic beverages.

• There is evidence suggesting lack of carcinogenicity in humans for alcoholic beverages and cancer of kidney and non-Hodgkin lymphoma. Limited evidence for pancreas.

• There is substantial mechanistic evidence in humans with aldehyde dehydrogenase deficiency that acetaldehyde derived from the metabolism of ethanol in alcoholic beverages contributes to the causation of malignant esophageal tumors.

• There is sufficient evidence in experimental animals for the carcinogenicity of ethanol.

• There is sufficient evidence in experimental animals for the carcinogenicity of acetaldehyde.

• Overall evaluation: Alcoholic beverages are carcinogenic to humans (Group 1). Ethanol in alcoholic beverages is carcinogenic to humans (Group 1). Acetaldehyde associated with alcohol consumption is carcinogenic to humans (Group 1).

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Alcohol-related evaluations of the WHO International Agency for Research on Cancer (IARC) .Pdf

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